精品午夜福利1000在线观看_欧美日韩亚洲综合一区二区三区激情_久久精品成人91一区二区_噜噜AV亚洲一区二区_色伊人久久综合中文字幕_色777一起草_亚洲中文字幕一二区_超碰在线国语,大但国模一区二区,AV无码成人精品区,拳交啪视频

加入收藏 | 設為首頁 | 聯(lián)系我們

產(chǎn)品搜索

聯(lián)系我們

聯(lián)系人：蔣經(jīng)理
電話：4008750250
號碼：
手機：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com

產(chǎn)品展示 / PRODUCTS
藥靶細胞株 > kinase激酶細胞株 > CBP73194ETV6-NTRK3/BaF3

ETV6-NTRK3/BaF3
名稱 ETV6-NTRK3/BaF3
型號 CBP73194
報價
特點 ETV6-NTRK3/BaF3,母細胞：BaF3，凍存條件：90% FBS+10% DMSO
  • 詳細內(nèi)容


CBP73194

I. Introduction

Cell Line Name：

ETV6-NTRK3/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10% FBS+1 ug/ml puromycin

Mycoplasma Status:

Negative


II.Background
ETV6-NTRK3 gene fusion is the translocation of genetic material between the ETV6 gene located on the short arm (designated p) of chromosome 12 at position p13.2 (i.e. 12p13.2) and the NTRK3 gene located on the long arm (designated q) of chromosome 15 at position q25.3 (i.e. 15q25.3) to create the (12;15)(p13;q25) fusion gene, ETV6-NTRK3. This new gene consists of the 5' end of ETV6 fused to the 3' end of NTRK3. ETV6-NTRK3 therefore codes for an chimeric oncoprotein consisting of the helix-loop-helix (HLH) protein dimerization domain of the ETV6 protein fused to the tyrosine kinase (i.e. PTK) domain of the NTRK3 protein. The ETV6 gene codes for the transcription factor protein, ETV6, which suppresses the expression of, and thereby regulates, various genes that in mice are required for normal hematopoiesis as well as the development and maintenance of the vascular network. NTRK3 codes for Tropomyosin receptor kinase C a NT-3 growth factor receptor cell surface protein that when bound to its growth factor ligand, neurotrophin-3, becomes an active tyrosine kinase that phosphorylates tyrosine residues on, and thereby stimulates, signaling proteins that promote the growth, survival, and proliferation of their parent cells. The tyrosine kinase of the ETV6-NTRK3 fusion protein is dysfunctional in that it is continuously active in phophorylating tyrosine residues on, and thereby continuously stimulating, proteins that promote the growth, survival, and proliferation of their parent cells. In consequence, these cells take on malignant characteristics and are on the pathway of becoming cancerous. Indeed, the ETV6-NTRK3 fusion gene appears to be a critical driver of several types of cancers. It was originally identified in congenital fibrosarcoma and subsequently found in secretory breast cancer (also termed juvenile breast cancer), Mammary analogue secretory carcinoma of salivary glands (also termed MASC or MASCSG), congenital fibrosarcoma, congenital mesoblastic nephroma, rare cases of acute myelogenous leukemia, ALK-negative Inflammatory myofibroblastic tumour, and radiation-induced papillary thyroid carcinoma.

III. Representative Data

1. WB of  ETV6-NTRK3/BaF3 expression

CBP73194 WB.jpg

2. Anti-proliferation assay

CBP73194 fig.png

Figure 2. Anti-proliferation assay of two reference compounds on the ETV6-NTRK3/BaF3 Stable Cell Line



如果你對CBP73194ETV6-NTRK3/BaF3感興趣，想了解更詳細的產(chǎn)品信息，填寫下表直接與廠家聯(lián)系：


留言框

  • 產(chǎn)品：

  • 您的單位：

  • 您的姓名：

  • 聯(lián)系電話：

  • 常用郵箱：

  • 省份：

  • 詳細地址：

  • 補充說明：

  • 驗證碼：

    請輸入計算結(jié)果（填寫阿拉伯數(shù)字），如：三加四=7

化工儀器網(wǎng)

推薦收藏該企業(yè)網(wǎng)站
黄色av。福利网导航| 99热在线播放| 亚洲国模一区二区| 亚洲一区二区自拍| 国产成a人亚洲精品无码久久网| 91丨九色丨国产丨人妻网站| 国产精品夜夜嗨视频免费视频| 婷婷色无码-久久久久久久久久毛片-成人AV | 精品国产乱码久久精品app| 国产aV高清一区二区三区 | 翔田千里AV无码| 69成人精品毛片在线播放| 国产精品高潮呻吟久久AV无码中文| 99久久最新视频| 欧美熟女肉感视频| 精品亲子伦无码| 99国产偷拍| 岛国av一区二区在线在线观看| 69不卡| 亚洲精品中文字幕蜜桃av| 97精品人人妻人人| 91欧美视频| 无码人妻精一区二区三区| 激情区小说区图片区成人区 | 无码人妻精品一区二区三区A片| 亚洲AV有码无码国产精品| 国产成人a亚洲精品无码AV| 日韩黄色av网站在线观看| 近親伦一区二区三区| 亚洲人成人无码网在线观看| 久久亚洲私人国产精品99| 亚洲 天天在线| 中文乱码人妻系列一区二区 | 国产做a爰片久久毛片| 国产午夜福利在线不卡视频| 99久久精品午夜一区| 午夜精品久久内射电影| 一起草AV一区二区三区| 97综合免费| 在线视频91专区| 免看老女人黄色A片特黄|